Article
Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region.
Translational psychiatry - 11 Feb 2021
Ikegame Tempei, Hidaka Yosuke, Nakachi Yutaka, Murata Yui, Watanabe Risa, Sugawara Hiroko, Asai Tatsuro, Kiyota Emi, Saito Takeo, Ikeda Masashi, Sasaki Tsukasa, Hashimoto Mamoru, Ishikawa Tomohisa, Takebayashi Minoru, Iwata Nakao, Kakiuchi Chihiro, Kato Tadafumi, Kasai Kiyoto, Bundo Miki, Iwamoto Kazuya
Abstract excerpt
SLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each of which has 14 or 16 tandem repeats. In addition, the extralong (XL) and other rare alleles have been reported in 5-HTTLPR. Although they are more frequent in Asian and African than in other populations,...
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