Article
Polycystin‐2 associates with the polycystin‐1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa
23 Feb 2004
Abstract excerpt
Polycystin-2, the protein mutated in type 2 autosomal dominant polycystic kidney disease, is an integral transmembrane protein with nonselective cation channel activity. Here we report on the sea urchin sperm homolog of polycystin-2 (suPC2). Like other polycystin-2 family members, suPC2 is a six-pass transmembrane protein containing C-terminal cytoplasmic EF hand and coiled-coil domains. The protein localizes...
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