Article
Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells.
The Journal of biological chemistry - 19 Sept 2003
Grimm David H, Cai Yiqiang, Chauvet Veronique, Rajendran Vanathy, Zeltner Raoul, Geng Lin, Avner Ellis D, Sweeney William, Somlo Stefan, Caplan Michael J
Abstract excerpt
Mutations in PKD1 and PKD2, the genes that encode polycystin-1 and polycystin-2 respectively, account for almost all cases of autosomal dominant polycystic kidney disease. Although the polycystins are believed to interact in vivo, the two proteins often display dissimilar patterns and gradients of expression during development. In an effort to understand this apparent discrepancy, we investigated how changes in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.