Article
The 10 sea urchin receptor for egg jelly proteins (SpREJ) are members of the polycystic kidney disease-1 (PKD1) family.
BMC genomics - 13 Jul 2007
Gunaratne H Jayantha, Moy Gary W, Kinukawa Masashi, Miyata Shinji, Mah Silvia A, Vacquier Victor D
Abstract excerpt
BACKGROUND: Mutations in the human polycystic kidney disease-1 (hPKD1) gene result in ~85% of cases of autosomal dominant polycystic kidney disease, the most frequent human monogenic disease. PKD1 proteins are large multidomain proteins involved in a variety of signal transduction mechanisms. Obtaining more information about members of the PKD1 family will help to clarify their functions. Humans have five hPKD1...
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