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Article

Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype.

Oncogene - 26 Feb 2004

Fukao Toshiyuki, Chen Philip, Ren Jun, Kaneko Hideo, Zhang Gai Xiu, Kondo Masahi, Yamamoto Ken-Ichi, Furuichi Yasuhiro, Takeda Shunichi, Kondo Naomi, Lavin Martin F

Abstract excerpt

Bloom syndrome and ataxia-telangiectasia are autosomal recessive human disorders characterized by immunodeficiency, genome instability and predisposition to develop cancer. Recent data reveal that the products of these two genes, BLM and ATM, interact and function together in recognizing abnormal DNA structures. To investigate the function of these two molecules in DNA damage recognition, we generated double...

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Identifiers

PMID: 14985700
DOI: 10.1038/sj.onc.1207276

Genes

ATM
BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype.PMID 14985700Read ↗

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATMSemantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.Semantic proximity Read ↗

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read ↗

Deficiency of Bloom syndrome helicase activity is radiomimetic.Semantic proximity Read ↗

Functional interactions between BLM and XRCC3 in the cell.Semantic proximity Read ↗

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesSemantic proximity Read ↗

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.Semantic proximity Read ↗

The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.Semantic proximity Read ↗

Enhanced tumor formation in mice heterozygous for Blm mutation.Semantic proximity Read ↗

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