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Article

The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.

Molecular and cellular biology - 1 Mar 2007

Babbe Holger, Chester Nicholas, Leder Philip, Reizis Boris

Abstract excerpt

Bloom's syndrome is a genetic disorder characterized by increased incidence of cancer and an immunodeficiency of unknown origin. The BLM gene mutated in Bloom's syndrome encodes a DNA helicase involved in the maintenance of genomic integrity. To explore the role of BLM in the immune system, we ablated murine Blm in the T-cell lineage. In the absence of Blm, thymocytes were severely reduced in numbers and...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to RecQ Helicases

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Source

Open in PubMed Open full text

Identifiers

PMID: 17210642
DOI: 10.1128/MCB.01402-06
PMCID: PMC1820471

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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