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Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

14 Jun 2004

Abstract excerpt

Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein. In BS cells, chromosomal abnormalities such as sister chromatid exchanges occur at highly elevated rates. Using Xenopus egg extracts, we have studied Xenopus BLM (Xblm) during both unperturbed and disrupted DNA replication cycles. Xblm binds to replicating...

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Identifiers

PMID: 15197177
DOI: 10.1083/jcb.200402095

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesPMID 15197177Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestSemantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.Semantic proximity Read ↗

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.Semantic proximity Read ↗

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Semantic proximity Read ↗

Functional interactions between BLM and XRCC3 in the cell.Semantic proximity Read ↗

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome ProteinSemantic proximity Read ↗

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.Semantic proximity Read ↗

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