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Article

Functional interactions between BLM and XRCC3 in the cell.

The Journal of cell biology - 8 Oct 2007

Otsuki Makoto, Seki Masayuki, Inoue Eri, Yoshimura Akari, Kato Genta, Yamanouchi Saki, Kawabe Yoh-ichi, Tada Shusuke, Shinohara Akira, Komura Jun-ichiro, Ono Tetsuya, Takeda Shunichi, Ishii Yutaka, Enomoto Takemi

Abstract excerpt

Bloom's syndrome (BS), which is caused by mutations in the BLM gene, is characterized by a predisposition to a wide variety of cancers. BS cells exhibit elevated frequencies of sister chromatid exchanges (SCEs), interchanges between homologous chromosomes (mitotic chiasmata), and sensitivity to several DNA-damaging agents. To address the mechanism that confers these phenotypes in BS cells, we characterize a...

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Source

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Identifiers

PMID: 17923529
DOI: 10.1083/jcb.200702183
PMCID: PMC2064734

Genes

BLM
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional interactions between BLM and XRCC3 in the cell.PMID 17923529Read ↗

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The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.Semantic proximity Read ↗

Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.Semantic proximity Read ↗

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATMSemantic proximity Read ↗

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.Semantic proximity Read ↗

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Semantic proximity Read ↗

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesSemantic proximity Read ↗

Transfection of BLM into cultured bloom syndrome cells reduces the sister-chromatid exchange rate toward normal.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

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