Article
Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S.
The protein journal - 1 Dec 2006
Srinivasulu Sonati, Perumalsamy Krishnaveni, Upadhya Rajendra, Manjula Belur N, Feiring Steven, Alami Raouf, Bouhassira Eric, Fabry Mary E, Nagel Ronald L, Acharya A Seetharama
Abstract excerpt
The linkage of pair-wise interactions of contact site mutations of HbS has been studied using Le Lamentin [His-20 (alpha)-->Gln], Hoshida [Glu-43 (beta)-->Gln] and alpha(2)beta (2) (T87Q) mutations as the prototype of three distinct classes of contact sites of deoxy HbS fiber. Binary mixture experiments established that beta(A)-chain with the Thr-87 (beta)-->Gln mutation is as potent as the gamma-chain of HbF...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.