Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.

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Article

Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.

Oncogene - 1 Apr 1991

Corominas M, Leon J, Kamino H, Cruz-Alvarez M, Novick S C, Pellicer A

Abstract excerpt

Activated H-ras genes are present in a number of skin tumors induced in animals by carcinogen treatment. The involvement of the ras oncogenes in tumorigenesis was investigated in keratoacanthomas, benign and self-regressing tumors, as well as malignant squamous cell carcinomas. Both tumors were induced in rabbit ears by repeated applications of 7,12 dimethylbenz(a)anthracene (DMBA). The rabbit H-ras gene was...

Topics

9,10-Dimethyl-1,2-benzanthracene
Amino Acid Sequence
Animals
Base Sequence
Carcinoma, Squamous Cell
Cloning, Molecular
DNA
Gene Expression Regulation, Neoplastic
Genes, ras
Keratoacanthoma
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Regression, Spontaneous

Polymerase Chain Reaction

RNA, Messenger

Rabbits

Sequence Homology, Nucleic Acid

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1840681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1840681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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