Comparison of significance level at the true location using two linkage approaches: LODPAL and GENEFINDER.

doi:10.1186/1471-2156-4-S1-S46

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Article

Comparison of significance level at the true location using two linkage approaches: LODPAL and GENEFINDER.

BMC genetics - 31 Dec 2003

Hsu Fang-Chi, Hetmanski Jacqueline B, Li Lan, Markakis Diane, Jacobs Kevin, Shugart Yin Yao

Abstract excerpt

BACKGROUND: We compare two new software packages for linkage analysis, LODPAL and GENEFINDER. Both allow for covariate adjustment. Replicates 1 to 3 of Genetic Analysis Workshop 13 simulated data sets were used for the analyses. We described the results of searching for evidence of loci contributing to a simulated quantitative trait related to systolic blood pressure (SBP). Individuals with SBP greater than 130...

Topics

Adult Children
Blood Pressure
Chromosome Mapping
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 7
Family
Female
Genetic Linkage
Humans
Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Matched-Pair Analysis

Phenotype

Quantitative Trait Loci

Quantitative Trait, Heritable

Siblings

Software

Source

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Identifiers

PMID: 14975114
DOI: 10.1186/1471-2156-4-S1-S46
PMCID: PMC1866482

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