Article
Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure.
BMC genetics - 31 Dec 2003
Shephard Neil, Falcaro Milena, Zeggini Eleftheria, Chapman Philip, Hinks Anne, Barton Anne, Worthington Jane, Pickles Andrew, John Sally
Abstract excerpt
BACKGROUND: The design of appropriate strategies to analyze and interpret linkage results for complex human diseases constitutes a challenge. Parameters such as power, definition of phenotype, and replicability have to be taken into account in order to reach meaningful conclusions. Incorporating data on repeated phenotypic measures may increase the power to detect linkage but requires sophisticated analysis...
Topics
- Adult Children
- Blood Pressure
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 21
- Cross-Sectional Studies
- Female
- Genetic Linkage
- Genetic Markers
- Genome, Human
- Humans
- Hypertension
- Linkage Disequilibrium