Article
Detection of susceptibility loci by genome-wide linkage analysis.
BMC genetics - 30 Dec 2005
Babron Marie-Claude, Bourgain Catherine, Leutenegger Anne-Louise, Clerget-Darpoux Françoise
Abstract excerpt
The objective of this study is to evaluate the efficacy of a model-free linkage statistics for finding evidence of linkage using two different maps and to illustrate how the comparison of results from several populations might provide insight into the underlying genetic etiology of the disease of interest. The results obtained in terms of detection of the risk loci and threshold for declaring linkage and power...
Topics
- Chromosome Mapping
- Genetic Linkage
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Microsatellite Repeats
- Polymorphism, Single Nucleotide
- Reproducibility of Results