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Article

Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteins.

Biochimica et biophysica acta - 1 Jul 2006

Tsiroulnikov Kirill, Rezaei Human, Dalgalarrondo Michèle, Chobert Jean-Marc, Grosclaude Jeanne, Haertlé Thomas

Abstract excerpt

One of symptoms of transmissible spongiform encephalopathies is associated with the transformation of normal cellular prion protein, PrP, in its amyloid isoform resistant to proteolytic cleavage. The present study shows that interaction with copper ions converts both monomeric recombinant scrapie-susceptible PrP-VRQ and scrapie-resistant PrP-ARR variants into protease-resistant soluble oligomers with amyloid...

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Identifiers

PMID: 16777497
DOI: 10.1016/j.bbapap.2006.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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