Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential pleiotropic effects of Mpdz on vulnerability to seizures.

Genes, brain, and behavior - 1 Feb 2004

Fehr C, Shirley R L, Metten P, Kosobud A E K, Belknap J K, Crabbe J C, Buck K J

Abstract excerpt

We previously mapped quantitative trait loci (QTL) responsible for approximately 26% of the genetic variance in acute alcohol and barbiturate (i.e., pentobarbital) withdrawal convulsion liability to a < 1 cM (1.8 Mb) interval of mouse chromosome 4. To date, Mpdz, which encodes the multiple PSD95/DLG/ZO-1 (PDZ) domain protein (MPDZ), is the only gene within the interval shown to have allelic variants that differ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Ethanol
Share to gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Mice, Inbred Strains

Share to Quantitative Trait, Heritable

Share to Seizures

Share to Substance Withdrawal Syndrome

Source

Identifiers

PMID: 14960011
DOI: 10.1111/j.1601-183x.2004.00035.x

Genes

MPDZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential pleiotropic effects of Mpdz on vulnerability to seizures.PMID 14960011Read ↗

Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.Semantic proximity Read ↗

Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry.Semantic proximity Read ↗

Mpdz is a quantitative trait gene for drug withdrawal seizures.Semantic proximity Read ↗

5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice.Semantic proximity Read ↗

Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.Semantic proximity Read ↗

Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence.Semantic proximity Read ↗

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.Semantic proximity Read ↗

Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in MiceSemantic proximity Read ↗

Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal.Semantic proximity Read ↗

Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice.Semantic proximity Read ↗

Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.Semantic proximity Read ↗

Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.