Article
Mpdz is a quantitative trait gene for drug withdrawal seizures.
Nature neuroscience - 1 Jul 2004
Shirley Renee L, Walter Nicole A R, Reilly Matthew T, Fehr Christoph, Buck Kari J
Abstract excerpt
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and...
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