Article
Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2002
Fehr Christoph, Shirley Renee L, Belknap John K, Crabbe John C, Buck Kari J
Abstract excerpt
Risk for onset of alcoholism is related to genetic differences in acute alcohol withdrawal liability. We previously mapped a locus responsible for 26% of the genetic variance in acute alcohol withdrawal convulsion liability to a >35 centimorgan (cM) interval of murine chromosome 4. Here, we narrow the position of this locus to a <1 cM interval (approximately 1.8 megabase, containing 15 genes and/or predicted...
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