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Article

5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice.

Brain research - 10 Mar 2008

Reilly Matthew T, Milner Lauren C, Shirley Renee L, Crabbe John C, Buck Kari J

Abstract excerpt

Progress towards elucidating the underlying genetic variation for susceptibility to complex central nervous system (CNS) hyperexcitability states has just begun. Genetic mapping analyses suggest that a gene(s) on mid-chromosome 4 has pleiotropic effects on multiple CNS hyperexcitability states in mice, including alcohol and barbiturate withdrawal and convulsions elicited by chemical and audiogenic stimuli. We...

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Source

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Identifiers

PMID: 18262506
DOI: 10.1016/j.brainres.2008.01.024
PMCID: PMC2322873

Genes

MPDZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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