Article
Cell migration patterns and ongoing somatic mutations in the progression of follicular lymphoma.
Cytogenetic and genome research - 1 Jan 2007
Adam P, Schoof J, Hartmann M, Schwarz S, Puppe B, Ott M, Rosenwald A, Ott G, Muller-Hermelink H K
Abstract excerpt
Follicular lymphoma (FL) constitutes the neoplastic equivalent of germinal center B-cells. Like its physiological counterpart, FL grows in (atypical) follicular structures, the formation of which is as yet poorly understood. Recent data indicate that in early tumour stages, neoplastic FL cells home to and colonise reactive germinal centers. Laser microdissection (LMD) and micromanipulation techniques now allow...
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