Article
IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.
The EMBO journal - 1 May 1992
High N, Mounier J, Prévost M C, Sansonetti P J
Abstract excerpt
By creating mutations within the Shigella flexneri ipaB gene, we have demonstrated that the invasion of epithelial cells is a three-step process encompassing adhesion on the cell surface, entry and lysis of the phagocytic vacuole allowing subsequent access to the cytoplasm. SC403, an insertion mu...
Topics
- Bacterial Adhesion
- Blotting, Western
- Epithelial Cells
- Epithelium
- Gene Expression
- Genes, Bacterial
- HeLa Cells
- Humans
- Macrophages
- Mutation
- Phagocytes
- Plasmids
- Restriction Mapping
- Shigella flexneri
- Vacuoles
- Virulence