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Article

SmD1 is required for spliced leader RNA biogenesis.

Eukaryotic cell - 1 Feb 2004

Zeiner Gusti M, Foldynová Silvie, Sturm Nancy R, Lukes Julius, Campbell David A

Abstract excerpt

The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected.

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Share to Alternative Splicing
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Share to DNA, Kinetoplast

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ribonucleoproteins, Small Nuclear

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Share to RNA Processing, Post-Transcriptional

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Source

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Identifiers

PMID: 14871954
DOI: 10.1128/EC.3.1.241-244.2004
PMCID: PMC329508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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