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Article

The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei.

Molecular and cellular biology - 1 Sept 2007

Zamudio Jesse R, Mittra Bidyottam, Foldynová-Trantírková Silvie, Zeiner Gusti M, Lukes Julius, Bujnicki Janusz M, Sturm Nancy R, Campbell David A

Abstract excerpt

mRNA cap 1 2'-O-ribose methylation is a widespread modification that is implicated in processing, trafficking, and translational control in eukaryotic systems. The eukaryotic enzyme has yet to be identified. In kinetoplastid flagellates trans-splicing of spliced leader (SL) to polycistronic precursors conveys a hypermethylated cap 4, including a cap 0 m7G and seven additional methylations on the first 4...

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Identifiers

PMID: 17606627
DOI: 10.1128/MCB.00647-07
PMCID: PMC1952150

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Source receipt: pubmed, retrieved 7 Sept 2026.

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