Article

Structural basis of Spliced Leader RNA recognition by the <i>Trypanosoma brucei</i> cap-binding complex

2024-05-05

Abstract excerpt

Kinetoplastids are a clade of eukaryotic protozoans that include human parasitic pathogens like trypanosomes and Leishmania species. In these organisms, protein-coding genes are transcribed as polycistronic pre-mRNAs, which need to be processed by the coupled action of trans-splicing and polyadenylation to yield monogenic mature mRNAs. During trans-splicing, a universal RNA sequence, the spliced leader RNA (SL RNA...

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Literature Corpus work: 3d059e46-e175-5163-b8a4-34beca76878f
DOI: 10.1101/2024.05.04.591051

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