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Article

Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.

International journal of molecular sciences - 5 Dec 2020

Brandes Nadine, Mitkovska Slavica Hristomanova, Botermann Dominik Simon, Maurer Wiebke, Müllen Anna, Scheile Hanna, Zabel Sebastian, Frommhold Anke, Heß Ina, Hahn Heidi, Uhmann Anja

Abstract excerpt

Basal cell carcinoma (BCC) originate from Hedgehog/Patched signaling-activated epidermal stem cells. However, the chemically induced tumorigenesis of mice with a CD4Cre-mediated biallelic loss of the Hedgehog signaling repressor Patched also induces BCC formation. Here, we identified the cellular origin of CD4Cre-targeted BCC progenitors as rare Keratin 5+ epidermal cells and show that wildtype Patched offspring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33291515
DOI: 10.3390/ijms21239295
PMCID: PMC7730243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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