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Article

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.

Nature - 23 Oct 1997

Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A

Abstract excerpt

Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a fraction of sporadic BCCs have lost the function of Patched (Ptc), a Sonic hedgehog (Shh) receptor that acts negatively on this signalling pathway. Overexpression of Shh can...

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Identifiers

PMID: 9349822
DOI: 10.1038/39918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9349822-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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