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Article

Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.

The Journal of investigative dermatology - 1 May 2013

Kang Hio Chung, Wakabayashi Yuichi, Jen Kuang-Yu, Mao Jian-Hua, Zoumpourlis Vassilis, Del Rosario Reyno, Balmain Allan

Abstract excerpt

Ptch1 is a key regulator of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway. Ptch1 is best known as a tumor suppressor, as germline or somatic mutations in Ptch1 lead to the formation of skin basal cell carcinomas. Here we show that Ptch1 also acts as a lineage-dependent oncogene, as overexpression of Ptch1 in adult skin in K14Ptch(FVB) transgenic mice synergizes with chemically...

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Source

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Identifiers

PMID: 23223138
DOI: 10.1038/jid.2012.419
PMCID: PMC3610826

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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