Article
Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines.
Oncology research - 1 Jan 1992
Reiss M, Brash D E, Muñoz-Antonia T, Simon J A, Ziegler A, Vellucci V F, Zhou Z L
Abstract excerpt
Dominant-negative and/or loss-of-function mutations of the p53 tumor suppressor gene are frequently found in squamous cell carcinomas of the skin and of the head-and-neck region. In order to identify the precise mechanisms of inactivation of p53 in tumors of this class, we examined the status of p53 RNA, protein and DNA in a panel of eight human squamous carcinoma cell lines (head-and-neck, 3; esophagus, 1; lung,...
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