Article
Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines.
Oncology research - 1 Jan 1992
Reiss M, Brash D E, Muñoz-Antonia T, Simon J A, Ziegler A, Vellucci V F, Zhou Z L
Abstract excerpt
Dominant-negative and/or loss-of-function mutations of the p53 tumor suppressor gene are frequently found in squamous cell carcinomas of the skin and of the head-and-neck region. In order to identify the precise mechanisms of inactivation of p53 in tumors of this class, we examined the status of...
Topics
- Base Sequence
- Blotting, Western
- Carcinoma, Squamous Cell
- Enzyme-Linked Immunosorbent Assay
- Gene Deletion
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Precipitin Tests
- RNA, Messenger
- RNA, Neoplasm
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53