Article
Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells.
American journal of obstetrics and gynecology - 1 Nov 1995
Hietanen S H, Kurvinen K, Syrjänen K, Grénman S, Carey T, McClatchey K, Syrjänen S
Abstract excerpt
OBJECTIVE: The purpose of this study was to evaluate the presence and type of mutations of the tumor suppressor gene p53 in squamous carcinoma cell lines of the vulva. STUDY DESIGN: Eight low-passage cell lines established from vulvar carcinoma were included in the analysis. Mutational analysis w...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Line
- DNA Mutational Analysis
- DNA Primers
- Exons
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Deletion
- Tumor Cells, Cultured
- Vulvar Neoplasms