Article
Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells.
American journal of obstetrics and gynecology - 1 Nov 1995
Hietanen S H, Kurvinen K, Syrjänen K, Grénman S, Carey T, McClatchey K, Syrjänen S
Abstract excerpt
OBJECTIVE: The purpose of this study was to evaluate the presence and type of mutations of the tumor suppressor gene p53 in squamous carcinoma cell lines of the vulva. STUDY DESIGN: Eight low-passage cell lines established from vulvar carcinoma were included in the analysis. Mutational analysis was restricted to exons 5 through 9 of the p53 gene, previously shown to have a high incidence of mutations. The...
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