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MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation

15 Sept 2006

Abstract excerpt

Gene amplification and protein overexpression of MDM2, which is often found in certain types of cancers, indicate that MDM2 plays an important role in tumorigenesis. Interestingly, several clinical reports have demonstrated that amplification of the MDM2 gene correlates with the metastatic stage. Using an antibody array assay, we identified E-cadherin as an MDM2-binding protein and confirmed that E-cadherin is a...

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PMID: 16980628
DOI: 10.1128/mcb.00172-06

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