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Article

BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.

Journal of cellular physiology - 1 Jun 2007

Liu Tingjiao, Gao Yuhao, Sakamoto Kei, Minamizato Tokutaro, Furukawa Keizo, Tsukazaki Tomoo, Shibata Yasuaki, Bessho Kazuhisa, Komori Toshihisa, Yamaguchi Akira

Abstract excerpt

To investigate the molecular mechanism underlying the differentiation of osteoblasts and chondroblasts, we established a clonal cell lines, RD-C6, from Runx2-deficient mouse embryos. RD-C6 cells expressed almost undetectable levels of phenotypes related to osteoblast and chondroblast differentiation at basal culture condition, whereas treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2) or...

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PMID: 17226753
DOI: 10.1002/jcp.20988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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