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Article

Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells

4 Jun 2008

Abstract excerpt

INTRODUCTION: Bone morphogenetic proteins (BMPs) are critical growth factors in the osteogenic differentiation of progenitor cells during development in embryos and fracture repair in adults. Although recombinant BMPs are in use clinically, their clinical efficiency needs to be improved. The biological activities of BMPs are naturally regulated by extracellular binding proteins. The specific hypotheses tested in...

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PMID: 18533030
DOI: 10.1186/ar2436

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