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Article

Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

The Journal of biological chemistry - 5 Jan 2007

Chen Yan, Whetstone Heather C, Youn Andrew, Nadesan Puviindran, Chow Edwin C Y, Lin Alvin C, Alman Benjamin A

Abstract excerpt

Endochondral ossification is recapitulated during bone morphogenetic protein (BMP)-induced ectopic bone formation. Although BMP and beta-catenin have been investigated in bone development and in mesenchymal cells, how they interact in this process is not clear. We implanted recombinant BMP-2 into the muscle of mice to investigate the effect of beta-catenin signaling on BMP-induced in vivo endochondral bone...

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PMID: 17085452
DOI: 10.1074/jbc.M602700200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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