Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP‐2 Induced Osteoblast Differentiation and Signaling

14 Oct 2013

Abstract excerpt

Connective tissue growth factor (CTGF/CCN2) and bone morphogenetic protein (BMP)-2 are both produced and secreted by osteoblasts. Both proteins have been shown to have independent effects in regulating osteoblast proliferation, maturation and mineralization. However, how these two proteins interact during osteoblast differentiation remains unknown. In this study, we utilized two cell culture model systems,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Connective Tissue Growth Factor Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24127409
DOI: 10.1002/jcp.24491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP‐2 Induced Osteoblast Differentiation and SignalingPMID 24127409Read ↗

Establishment of Immortalized BMP2/4 Double Knock-Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis.Semantic proximity Read ↗

BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.Semantic proximity Read ↗

Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.Semantic proximity Read ↗

TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiationSemantic proximity Read ↗

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.Semantic proximity Read ↗

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone developmentSemantic proximity Read ↗

Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cellsSemantic proximity Read ↗

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12Semantic proximity Read ↗

Temporal activation of β-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated.Semantic proximity Read ↗

Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca+-CAMK2A-CREBSemantic proximity Read ↗

14-3-3γ Knockdown Promotes Matrix Mineralization in human Mesenchymal Stromal CellsSemantic proximity Read ↗

Osteogenic differentiation of mesenchymal stem cells promoted by overexpression of connective tissue growth factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.