Article
Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors.
The Journal of biological chemistry - 8 Sept 2006
Risinger George M, Hunt Tamara S, Updike Dawn L, Bullen Elizabeth C, Howard Eric W
Abstract excerpt
In response to growth factors, vascular smooth muscle cells (VSMCs) undergo a phenotypic modulation from a contractile, non-proliferative state to an activated, migratory state. This transition is characterized by changes in their gene expression profile, particularly by a significant down-regulation of contractile proteins. Platelet-derived growth factor (PDGF)-BB has long been known to initiate VSMC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.