Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.

doi:10.1016/j.atherosclerosis.2008.07.036

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Article

Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.

Atherosclerosis - 1 Apr 2009

Kotha Jayaprakash, Zhang Chunxiang, Longhurst Celia M, Lu Yi, Jacobs Jonathan, Cheng Yunhui, Jennings Lisa K

Abstract excerpt

Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary artery smooth muscle (hCASM) cells were reduced by 40% and 63%, respectively, by treatment with...

Topics

Adenoviridae
Animals
Antigens, CD
Cell Movement
Cell Proliferation
Coronary Vessels
Humans
Integrin alpha5beta1
Male
Membrane Glycoproteins
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Muscle, Smooth, Vascular

Phenotype

Proto-Oncogene Proteins c-akt

Rats

Tetraspanin 29

Source

Open in PubMed

Identifiers

PMID: 18799160
DOI: 10.1016/j.atherosclerosis.2008.07.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.PMID 18799160Read ↗

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