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Article

Learning from directed evolution: theoretical investigations into cooperative mutations in lipase enantioselectivity.

Chembiochem : a European journal of chemical biology - 6 Feb 2004

Bocola Marco, Otte Nikolaj, Jaeger Karl-Erich, Reetz Manfred T, Thiel Walter

Abstract excerpt

Molecular modeling with classical force-fields has been used to study the reactant complex and the tetrahedral intermediate in lipase-catalyzed ester hydrolysis in 20 enzyme/substrate combinations. The R and S enantiomers of alpha-methyldecanoic acid ester served as substrates for the wild-type l...

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PMID: 14760743
DOI: 10.1002/cbic.200300731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14760743-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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