Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope.

Journal of the American Chemical Society - 6 Feb 2013

Wu Qi, Soni Pankaj, Reetz Manfred T

Abstract excerpt

Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic and industrial laboratories with many different kinds of applications. In fine chemicals production, examples include acylating kinetic resolution of racemic secondary alcohols and amines as well as desymmetrization of prochiral diols (or the reverse hydrolytic reactions). However, in the case of hydrolytic kinetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohols
Share to Biocatalysis
Share to Carboxylic Acids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Esters

Share to Hydrolysis

Share to Laboratories

Share to Lipase

Share to Stereoisomerism

Source

Identifiers

PMID: 23301759
DOI: 10.1021/ja310455t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope.PMID 23301759Read ↗

Creating space for large secondary alcohols by rational redesign of Candida antarctica lipase B.Semantic proximity Read ↗

Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.Semantic proximity Read ↗

Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols.Semantic proximity Read ↗

Expanding the substrate scope of enzymes: combining mutations obtained by CASTing.Semantic proximity Read ↗

New efficient recombinant expression system to engineer Candida antarctica lipase B.Semantic proximity Read ↗

Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity.Semantic proximity Read ↗

Computational design of a lipase for catalysis of the Diels-Alder reaction.Semantic proximity Read ↗

Improving the expression yield of Candida antarctica lipase B in Escherichia coli by mutagenesis.Semantic proximity Read ↗

Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution.Semantic proximity Read ↗

Computational approach for designing thermostable Candida antarctica lipase B by molecular dynamics simulation.Semantic proximity Read ↗

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.Semantic proximity Read ↗

Rational creation of mutant enzyme showing remarkable enhancement of catalytic activity and enantioselectivity toward poor substrates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.