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Article

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.

Scientific reports - 25 Mar 2024

Tam Kevin J, Liu Liangliang, Hsing Michael, Dalal Kush, Thaper Daksh, McConeghy Brian, Yenki Parvin, Bhasin Satyam, Peacock James W, Wang Yuzhuo, Cherkasov Artem, Rennie Paul S, Gleave Martin E, Ong Christopher J

Abstract excerpt

FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35%. However, despite the frequent recurrence of FOXA1 mutations in prostate cancer, the mechanisms by which FOXA1 variants drive its oncogenic effects are still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38528115
DOI: 10.1038/s41598-024-57854-w
PMCID: PMC10963789

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