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Article

A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.

Clinical and experimental pharmacology & physiology - 1 Jan 2000

Watanabe Takeshi K, Okuno Shiro, Yamasaki Yuki, Ono Toshihide, Oga Keiko, Mizoguchi-Miyakita Ayako, Miyao Hideo, Suzuki Mikio, Momota Hiroshi, Goto Yoshihiro, Shinomiya Hiroichi, Hishigaki Haretsugu, Hayashi Isamu, Asai Toshihiro, Wakitani Shigeyuki, Takagi Toshihisa, Nakamura Yusuke, Tanigami Akira

Abstract excerpt

1. Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes of male Otsuka Long Evans Tokushima Fatty (OLETF) rats. 2. Our congenic lines, produced by transferring Dmo1 chromosomal segments from the non-diabetic Brown Norway (BN) rat into the OLETF strain, have confirmed the strong, wide-range therapeutic effects of Dmo1 on dyslipidaemia, obesity...

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Source

Identifiers

PMID: 14756694
DOI: 10.1111/j.1440-1681.2004.03959.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.PMID 14756694Read ↗

Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.Semantic proximity Read ↗

Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.Semantic proximity Read ↗

Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.Semantic proximity Read ↗

Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.Semantic proximity Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.Semantic proximity Read ↗

Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.Semantic proximity Read ↗

Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.Semantic proximity Read ↗

Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.Semantic proximity Read ↗

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