Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.

Clinical and experimental pharmacology & physiology - 1 Jan 2000

Watanabe Takeshi K, Suzuki Mikio, Yamasaki Yuki, Okuno Shiro, Hishigaki Haretsugu, Ono Toshihide, Oga Keiko, Mizoguchi-Miyakita Ayako, Tsuji Atsushi, Kanemoto Naohide, Wakitani Shigeyuki, Takagi Toshihisa, Nakamura Yusuke, Tanigami Akira

Abstract excerpt

1. We have confirmed the Diabetes Mellitus OLETF type I (Dmo1) effect on hyperphagia, dyslipidaemia and obesity in the Otsuka Long-Evans Tokushima Fatty (OLETF) strain. The critical interval was narrowed down to 570 kb between D1Got258 to p162CA1 by segregation analyses using congenic lines. 2. W...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dyslipidemias
Share to Hyperphagia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Obesity

Share to Quantitative Trait Loci

Share to Rats, Inbred BN

Share to Receptors, G-Protein-Coupled

Share to Species Specificity

Source

Identifiers

PMID: 15854142
DOI: 10.1111/j.1440-1681.2005.04196.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-15854142-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.PMID 15854142Read ↗

Altered emotional behaviors in the diabetes mellitus OLETF type 1 congenic rat.Semantic proximity Read ↗

A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.Semantic proximity Read ↗

Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.Semantic proximity Read ↗

Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.Semantic proximity Read ↗

Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.Semantic proximity Read ↗

Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.Semantic proximity Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.Semantic proximity Read ↗

X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.Semantic proximity Read ↗

A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.