Article
Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.
Diabetes, obesity & metabolism - 1 Sept 2002
Okuno S, Kondo M, Yamasaki Y, Miyao H, Ono T, Iwanaga T, Omori K, Okano M, Suzuki M, Momota H, Hishigaki H, Hayashi I, Goto Y, Shinomiya H, Harada Y, Hirashima T, Kanemoto N, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A, Watanabe T K
Abstract excerpt
AIM: Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes in the Otsuka Long Evans Tokushima Fatty (OLETF) rat strain. To evaluate possible metabolic and pathological improvements generated by correction of the Dmo1 genetic pathway, we produced congenic lines, in which both OLETF Dmo1 alleles are replaced by the F344-derived genome. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.