Article
Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.
Genetical research - 1 Apr 2001
Okuno S, Watanabe T K, Ono T, Oga K, Mizoguchi-Miyakita A, Yamasaki Y, Goto Y, Shinomiya H, Momota H, Miyao H, Hayashi I, Asai T, Suzuki M, Harada Y, Hishigaki H, Wakitani S, Takagi T, Nakamura Y, Tanigami A
Abstract excerpt
Whole-genome scans have identified Dmo1 as a major quantitative trait locus (QTL) for obesity and dyslipidaemia in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. We have produced congenic rats for the Dmo1 locus, using marker-assisted speed congenic protocols, enforced by selective removal of other QTL regions (QTL-marker-assisted counterselection), to efficiently transfer chromosomal segments from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.