Article
Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection.
Behavior genetics - 1 Mar 2004
Shete Sanjay, Beasley T Mark, Etzel Carol J, Fernández José R, Chen Jianfang, Allison David B, Amos Christopher I
Abstract excerpt
Variance components analysis provides an efficient method for performing linkage analysis for quantitative traits. However, power and type 1 error of variance components-based likelihood ratio testing may be affected when phenotypic data are nonnormally distributed (especially with high values of kurtosis) and there is moderate to high correlation among the siblings. Winsorization can reduce the effect of...
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