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Article

Improving the power of sib pair quantitative trait loci detection by phenotype winsorization.

Human heredity - 1 Jan 2002

Fernández José R, Etzel Carol, Beasley T Mark, Shete Sanjay, Amos Christopher I, Allison David B

Abstract excerpt

OBJECTIVES: In sib pair studies, quantitative trait loci (QTL) identification may be adversely affected by non-normality in the phenotypic distribution, particularly when subjects falling in the tails of the distribution bias the trait mean or variance. We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three...

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PMID: 12037405
DOI: 10.1159/000057984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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