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Article

Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure.

American journal of human genetics - 1 Jul 2000

Allison D B, Fernández J R, Heo M, Beasley T M

Abstract excerpt

Variance components (VC) techniques have emerged as among the more powerful methods for detection of quantitative-trait loci (QTL) in linkage analysis. Allison et al. found that, with particularly marked leptokurtosis in the phenotypic distribution and moderate-to-high residual sibling correlation, maximum likelihood (ML) VC methods may produce a severe excess of type I errors. The new Haseman-Elston (NHE) method...

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PMID: 10820126
DOI: 10.1086/302966
PMCID: PMC1287085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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