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Article

p27(Kip1) and p21(Cip1)-independent proliferative inhibition of vascular smooth muscle cells cultured in type-I collagen matrix honeycombs.

Microvascular research - 1 Jan 2016

Uchida Masashi, Suzuki Saki, Suzuki Takaaki, Ishii Itsuko

Abstract excerpt

The proliferation of vascular smooth muscle cells (SMCs) contributes to atherosclerotic plaque formation and restenosis. Cyclin-dependent kinase inhibitors, such as p27(Kip1) and p21(Cip1), are known to play significant roles in the control of the aberrant proliferation of SMCs. Primary cultured SMCs stop proliferating immediately when cultured in three-dimensional matrices of type-I collagen "honeycombs"...

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PMID: 26522285
DOI: 10.1016/j.mvr.2015.10.003

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