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Article

Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species.

American journal of physiology. Cell physiology - 1 Jan 2006

Milovanova Tatyana, Chatterjee Shampa, Manevich Yefim, Kotelnikova Irina, Debolt Kris, Madesh Muniswamy, Moore Jonni S, Fisher Aron B

Abstract excerpt

Acute cessation of flow (ischemia) leads to depolarization of the endothelial cell (EC) membrane mediated by K(ATP) channels and followed by production of reactive oxygen species (ROS) from NADPH oxidase. We postulated that ROS are a signal for initiating EC proliferation associated with the loss of shear stress. Flow cytometry was used to identify proliferating CD31-positive pulmonary microvascular endothelial...

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PMID: 16107509
DOI: 10.1152/ajpcell.00094.2005

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ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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