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Article

Loss of p53 compensates for alpha v-integrin function in retinal neovascularization.

The Journal of biological chemistry - 19 Apr 2002

Strömblad Staffan, Fotedar Arun, Brickner Howard, Theesfeld Chandra, Aguilar de Diaz Edith, Friedlander Martin, Cheresh David A

Abstract excerpt

alpha(v)-Integrin antagonists block neovascularization in various species, whereas 20% of alpha(v)-integrin null mice are born with many normal looking blood vessels. Given that blockade of alpha(v)-integrins during angiogenesis induces p53 activity, we utilized p53 null mice to elucidate whether loss of p53 can compensate for alpha(v)-integrin function in neovascularization of the retina. Murine retinal...

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Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11856728
DOI: 10.1074/jbc.C200044200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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