Article
A tRNA suppressor mutation in human mitochondria.
Nature genetics - 1 Apr 1998
El Meziane A, Lehtinen S K, Hance N, Nijtmans L G, Dunbar D, Holt I J, Jacobs H T
Abstract excerpt
Mitochondrial mutations are associated with a wide spectrum of human diseases. A common class of point mutations affects tRNA genes, and mutations in the tRNA-leu(UUR) gene (MTTL1) are the most frequently detected. In earlier studies, we showed that lung carcinoma cybrid cells containing high lev...
Topics
- Anticodon
- Blotting, Northern
- DNA Mutational Analysis
- DNA, Mitochondrial
- Humans
- Mitochondria
- Phenotype
- Point Mutation
- Polymerase Chain Reaction
- RNA, Transfer, Leu
- Suppression, Genetic
- Tumor Cells, Cultured