Article
Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
The EMBO journal - 17 Jun 1996
Forrest D, Hanebuth E, Smeyne R J, Everds N, Stewart C L, Wehner J M, Curran T
Abstract excerpt
The diverse functions of thyroid hormone (T3) are presumed to be mediated by two genes encoding the related receptors, TRalpha and TRbeta. However, the in vivo functions of TRalpha and TRbeta are undefined. Here, we report that targeted inactivation of the mouse TRbeta gene results in goitre and...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Disease Models, Animal
- Female
- Genes, Recessive
- Homozygote
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Receptors, Thyroid Hormone